NFL Week 1 Picks Against the Spread · Sep 12, 2026 · 57:00
Contenders, Upsets & Season Predictions
The NFL is back, and Caine and Touchdown are putting their football knowledge on the record. Before jumping into the Week 1 slate, the guys talk through their early expectations for the season, including which teams look like legitimate contenders, who could surprise, and which players and quarterbacks they’re watching as the year gets underway. Then it’s time to make the picks. Caine and Touchdown work through the NFL Week 1 matchups and make their picks against the spread, with plenty of disagreements, side debates, and predictions along the way. In this episode:
In this episode
01Early NFL season predictions and expectations
02Which teams actually look like Super Bowl contenders
03Kansas City, Denver and the AFC picture
04Teams and players we're watching heading into the season
05Week 1 matchup breakdowns
06Picks against the spread
07Caine vs. Touchdown head-to-head picks
08Upset possibilities and games that could get interesting
09The beginning of the season-long Caine vs. Touchdown picks battle
10Picks are for entertainment purposes only. Betting lines discussed reflect the numbers available at the time of recording and may change before kickoff.
How this week graded
New England Patriots@Seattle Seahawks
CaineSeattle Seahawks -3.5✕TouchdownSeattle Seahawks -3.5✕
San Francisco 49ers@Los Angeles Rams
CaineLos Angeles Rams -3.5✕TouchdownLos Angeles Rams -3.5✕
Chicago Bears@Carolina Panthers
CaineChicago Bears -3✓TouchdownCarolina Panthers +3✕
Tampa Bay Buccaneers@Cincinnati Bengals
CaineTampa Bay Buccaneers +3.5✕TouchdownCincinnati Bengals -3.5✓
Atlanta Falcons@Pittsburgh Steelers
CaineAtlanta Falcons +3.5✕TouchdownAtlanta Falcons +3.5✕