NFL Week 2 Preview & ATS Picks · Sep 17, 2026 · 51:00
Bills-Lions, Bears Hype & Our Full Week 2 Card
Caine and Touchdown are back for Episode 5 with a full preview of NFL Week 2 and picks against the spread for the entire slate. Before getting into the picks, the guys react to what stood out most from Week 1 — including the Saints’ surprising performance, Cleveland’s quarterback situation, Baltimore looking like one of the league’s most complete teams, and Chicago’s explosive start. Then it’s time to go game by game.
In this episode
01Can the Bills take care of Detroit on Thursday Night Football?
02Are Caleb Williams and the Bears for real?
03Can the Eagles cover a touchdown on the road?
04Is New England getting too much respect against Pittsburgh?
05Can Houston slow down Joe Burrow and Ja’Marr Chase?
06Jaguars or Broncos after completely different Week 1 performances?
07Caine and Touchdown split on Commanders-Cowboys
08Can the Rams bounce back on Monday Night Football?
09Plus picks ATS for the full NFL Week 2 schedule
10Caine & Touchdown
11NFL • College Football • Picks • Reactions • Debate
How this week graded
Detroit Lions@Buffalo Bills
CaineBuffalo Bills -5.5✓TouchdownBuffalo Bills -5.5✓
Pittsburgh Steelers@New England Patriots
CainePittsburgh Steelers +5.5✕TouchdownPittsburgh Steelers +5.5✕
Cleveland Browns@Tampa Bay Buccaneers
CaineTampa Bay Buccaneers -8.5✕TouchdownTampa Bay Buccaneers -8.5✕
Cincinnati Bengals@Houston Texans
CaineHouston Texans -2.5✕TouchdownCincinnati Bengals +2.5✓
Carolina Panthers@Atlanta Falcons
CaineCarolina Panthers -2.5✓TouchdownCarolina Panthers -2.5✓