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CFB Week 5 Picks · Oct 3, 2026 · 45:00

Alabama-Mississippi State, Miami-Clemson & ATS Picks

Week 5 is here, and Caine & Touchdown are picking every Top 25 matchup against the spread. We break down a loaded Saturday slate featuring #7 Alabama at #16 Mississippi State, #5 Ohio State at #14 Iowa, #8 Florida at #25 Missouri, #4 Miami at Clemson and more. Touchdown thinks Miami could walk into Death Valley and make things ugly. Caine is putting his faith in Clemson to at least keep it respectable — and somehow decides Iowa has officially earned his attention, which historically hasn't gone well for anybody. We also get into whether Mississippi State can really hang with Alabama, why we're buying Florida, whether Auburn is actually any good, Colorado vs. Texas Tech, Georgia continuing to roll, a ridiculous 54.5-point LSU spread, and every other ranked matchup on the board. Every Top 25 game. Every spread. Caine vs. Touchdown. Follow the season-long picks and records at caineandtouchdown.com

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In this episode

How this week graded

Boston College Eagles@SMU MustangsCaineBoston College Eagles +21✓TouchdownBoston College Eagles +21✓
Notre Dame Fighting Irish@North Carolina Tar HeelsCaineNotre Dame Fighting Irish -21.5✕TouchdownNotre Dame Fighting Irish -21.5✕
Alabama Crimson Tide@Mississippi State BulldogsCaineAlabama Crimson Tide -5.5✓TouchdownAlabama Crimson Tide -5.5✓
UCF Knights@Houston CougarsCaineUCF Knights +11.5✓TouchdownUCF Knights +11.5✓
Vanderbilt Commodores@Georgia BulldogsCaineGeorgia Bulldogs -24.5✕TouchdownGeorgia Bulldogs -24.5✕

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